Major Features:

[New Features]

• Garuda enabled:
  New [Garuda] menu to connect to Garuda platform (http://gateway.garuda-alliance.org)
  
• New Plugin API: reaction label + connection point handling
  
• macOS Mojave support
  
• Ubuntu 18.04 support

[Updates in CellDesigner 4.4.2]

• CellDesigner now uses Java 8 (JRE bundled)
  
• Changed to use new BioModels API (thanks to Mihai Glon? and Tung Nguyen @ EBI)
  
• Add "PDF export" of simulation result
  
• "Stroke Width" can be changed while exporting simulation result to an image file.

[Bug Fixes in CellDesigner 4.4.2]

• Fixed BioModels.net file importing GO annotation ID
  
• Fixed an issue that CellDesigner fails to launch on some Windows 64bit environments
  
• Fixed SGD integration (updated URL)
  
• Fixed MetaCyc integration (updated URL)
  
• Fixed KineticLaw Editor so that equations will be correctly rendered on Windows
  
• and several minor bugs

[Known problems]

• Copasi GUI: focus out from Copasi panel when the mouse pointer moves out
  
• SBW connection: Some SBW modules may not work correctly

File Compatibilities

When you read the files created by lower version of CellDesigner,
CellDesigner 4.4.2 validates the file using libSBML consistency check utility.

1. Open a file created by lower version of CellDesinger.
   
2. Compartment's size attributes are automatically updated.
   
3. File conversion needed dialog is open.
   "The file seems to be created by lower version of CellDesigner.
   Do you want to convert this model to work with the current version?"
   
4. The file is converted and open with CellDesigner4.4.2.

With CellDesigner 4.0:

Due to the CellDesigner 4.0 new notation scheme, the following components are no longer supported.
Please edit the original files and redraw them with 4.2 components.

• Transcriptional activation -> catalysis shape
  
• Transcriptional inhibition -> inhibition shape
  
• Translational activation -> catalysis shape
  
• Translational inhibition -> inhibition shape
• Tag (4.0 beta files only) -> cannot open file.
  * delete it with 4.0beta and reopen it with CellDesigner4.0.

Installation:

For details on installation procedure, check here.